研究業績

Original Papers 2017

Yasuda K, Yogo Y, Sugimoto H, Mano H, Takita T, Ohta M, Kamakura M, Ikushiro S, Yasukawa K, Shiro Y, and Sakaki T: “Production of An Active Form of Vitamin D2 by Genetically Engineered CYP105A1”, Biochem. Biophys. Res. Commun. 486, 336-341 (2017)
Yasuda K, Sugimoto H, Hayashi K, Takita T, Yasukawa K, Ohta M, Kamakura M, Ikushiro S, Shiro Y, and Sakaki T: “Protein Engineering of CYP105s for Their Industrial Uses”, Biochim. Biophys. Acta S1570-9639, 30120-30126 (2017)
Shoji O, Yanagisawa S, Stanfield JK, Suzuki K, Cong Z, Sugimoto H, Shiro Y, and Watanabe Y: “Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives”, Angew. Chem. Int. Ed. Engl. 56, 10324-10329 (2017)
Terasaka E, Yamada K, Wang PH, Hosokawa K, Yamagiwa R, Matsumoto K, Ishii S, Mori T, Yagi K, Sawai H, Arai H, Sugimoto H, Sugita Y, Shiro Y, and Tosha T: “Dynamics of Nitric Oxide Controlled by Protein Complex in Bacterial System”, Proc. Natl. Acad. Sci. USA (2017) in press
Tosha T, Nomura T, Nishida T, Saeki N, Okubayashi K, Yamagiwa R, Sugahara M, Nakane T, Yamashita K, Hirata K, Ueno G, Kimura T, Hisano T, Muramoto K, Sawai H, Takeda H, Mizohata E, Yamashita A, Kanematsu Y, Takano Y, Nango E, Tanaka R, Nureki O, Ikemoto Y, Murakami H, Owada S, Tono K, Yabashi M, Yamamoto M, Ago H, Iwata S, Sugimoto H, Shiro Y, and Kubo M: “Capturing an Initial Intermediate during Enzymatic Reaction of P450nor using Time-Resolved XFEL Crystallography and Caged-Substrate”, Nature Communications (2017) in press
Kohyama-Koganeya A, Kurosawa M, and Hirabayashi Y “Loss of Boss Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila” PLOS ONE 3;12(1):e0169073 (2017)
Tsurumaki H, Katano H, Sato K, Imai R, Niino S, Hirabayashi Y, and Ichikawa S:“WP1066, a small molecule inhibitor of the JAK/STAT3 pathway, inhibits ceramide glucosyltransferase activity”, Biochem Biophys Res Commun. pii: S0006-291X(17)31473-0. (2017)
Abe M, and Kobayashi T: "Dynamics of sphingomyelin- and cholesterol- enriched lipid domains during cytokinesis" Methods Cell Biol 137, 15-24 (2017)
Kinoshita M, Suzuki K, Matsumori N, Takeda M, Ano H, Morigaki K, Abe M, Makino A, Kobayashi T, Hirosawa K, Fujiwara T, Kusumi A, and Murata M: "Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs" J Cell Biol 216, 1183-1204 (2017)
Wilhelm LP, Wendling C, Vedie B, Kobayashi T, Chenard M-P, Tomasetto C, Drin G, and Alpy F: "STARD3 mediates ER to endosome cholesterol transport at membrane contact sites" EMBO J 36, 1412-1433 (2017)
Makino A, Abe M, Ishitsuka R, Murate M, Kishimoto T, Sakai S, Hullin-Matsuda F, Shimada Y, Inaba T, Miyatake H, Tanaka H, Kurahashi A, Pack CG, Kasai RS, Kubo S, Schieber NL, Dohmae N, Tochio N, Hagiwara K, Sasaki Y, Aida Y, Fujimori F, Kigawa T, Nishibori K, Parton RG, Kusumi A, Sako Y, Anderluh G, Yamashita M, Kobayashi T, Greimel P, and Kobayashi T: A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C. FASEB J 31, 1301-1322 (2017)
Sumi M, Makino A, Inaba T, Sako Y, Fujimori F, Greimel P, and Kobayashi T: Photoswitchable phospholipid FRET acceptor: Detergent free intermembrane transfer assay of fluorescent lipid analogs. Sci Rep 7, 2900, (2017)
Yilmaz N, Yamaji-Hasegawa A, Hullin-Matsuda F, and Kobayashi T: "Molecular mechanisms of the action of sphingomyelin-specific pore-forming toxin, lysenin" Sem Cell Dev Biol, (2017) in press
Matsunaga S, Shimizu H, Yamada T, Kobayashi T, and Kawai M: "In Situ STM and vibrational study of nanometer-scale reorganization of a phospholipid monolayer accompanied by potential-driven headgroup digestion", Langmuir (2017) in press (cover article)
Okazaki Y, Takano K, and Saito K:“Lipidomic analysis of soybean leaves revealed tissue-dependent difference in lipid remodeling under phosphorus-limited growth conditions”, Plant Biotechnology, 34, 57-63 (2017)
Guan X, Okazaki Y, Lithio A, Li L, Zhao X, Jin H, Nettleton D, Saito K, and Nikolau BJ: “Discovery and characterization of the 3-hydroxyacyl-ACP dehydratase component of the plant mitochondrial fatty acid synthase system”, Plant Physiology, 173, 2010-2028 (2017)
Ealey KN, Moro K, and Koyasu S: "Are ILC2s Jekyll and Hyde in airway inflammation?" Immunol. Rev. 278:207-218. (2017)
Wagner M, Moro K, and Koyasu S: "Plastic heterogeneity of innate lymphoid cells in cancer" Trends Cancer 5: 326-335. (2017)
Balan S, Yamada K, Iwayama Y, Hashimoto T, Toyota T, Shimamoto C, Maekawa M, Takagai S, Wakuda T, Kameno Y, Kurita D, Yamada K, Kikuchi M, Hashimoto T, Kanahara N, and Yoshikawa T: "Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia" Schizophrenia Research 185: 33-40, (2017)
Ohnishi T, Miura I, Ohba H, Shimamoto C, Iwayama Y, Wakana S, and Yoshikawa T: "A Spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects" Gene 607: 16-22, (2017)
Gerstner JR, Perron IJ, Riedy SM, Yoshikawa T, Kadotani H, Owada Y, Van Dongen HPA, Galante R, Dickinson J, Yin JCP, Pack AI, and Frank MG: "Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7" Science Advances 3: e1602663, (2017)
Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, and Yoshikawa T: "Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes" Translational Psychiatry 7: e1229, (2017)
Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash AR, Ikeda K, Arita M, Akiyama M, and Murakami M: "PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis" Nature Commun 8, 14609 (2017)
Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash AR, Ikeda K, Arita M, Akiyama M, and Murakami M: "PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis" Nature Commun 8, 14609 (2017)
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, and Ohtani N: "Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity" Cancer Discov 7, 522-538 (2017)
Tsugawa H, Ikeda K, Tanaka W, Senoo Y, Arita M, and Arita M: "Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library" J Cheminform. 9, 19 (2017)
Ikutani M, Tsuneyama K, Kawaguchi K, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, and Takatsu K: "Prolonged activation of IL-5 producing ILC2 causes pulmonary arterial hypertrophy" JCI Insight 2, e90721 (2017)
Codagnone M, Cianci E, Lamolinara A, Cecilia Mari V, Nespoli A, Arita M, Bragonzi A, Iezzi M, Romano M, and Recchiuti A: "Resolvin D1 is immunoresolvent of lung inflammation caused by pseudominas aeruginosa acute and chronic infections" Mucosal Immunol (2017) in press
Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, Hirota Y, Fujii T, Tsuchiya S, Taketomi Y, Sugimoto Y, Murakami M, Arita M, Kurano M, Ikeda H, Yatomi Y, Chun J, and Aoki J: "Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways" EMBO J 36, 2146-2160 (2017)
Takahashi H, Shida D, Tagawa K, Iwamoto R, Arita M, Arai H, and Suzuki T: "Therapeutic effects of flurbiprofen axetil on mesenteric traction syndrome: randomized clinical trial" BMC Surg 17, 90 (2017)
Tsugawa H, Ikeda K, Arita M: "The importance of bioinformatics for connecting data-driven lipidomics and biological insights" Biochim Biophys Acta 1862, 762-765 (2017)
Kimura M, Morinaka Y, Imai K, Kose S, Horton P, and Imamoto N:“Extensive cargo identification reveals distinct biological roles of the 12 importin pathways.” eLife 6, e21184s (2017)
Izumi M, Mizuno T, Yanagi K, Sugimura K, Okumura K, Imamoto N, Abe T, and Hanaoka F: “The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) proteins is important for stable chromatin association and origin firing.” J. Biol., Chem., 292, 13008-13021 (2017).
Rahman KMZ, Mamada H, Takagi M, Kose S, and Imamoto N: “Hikeshi modulates the proteotoxic stress response in human cells: implication for the importance of the nuclear function of HSP70s.” Genes Cells, in press
Yoshizawa R, Umeki N, Yanagawa M, Murata M, Sako Y: "Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral" Biophysics and Physicobiology, vol 14, 75-84 (2017)
Kojima K, Matsutani Y, Yamashita T, Yanagawa M, Imamoto Y, Yamano Y, Wada A, Hisatomi O, Nishikawa K, Sakurai K, Shichida Y: "Adaptation of cone pigments found in green rods for scotopic vision through a single amino acid mutation" Proc. Natl. Acad. Sci. USA, 114(21):5437-5442. (2017)

Kohyama-Koganeya A, Kurosawa M, Hirabayashi Y “Loss of Boss Causes Shortened Lifespan with Mitochondrial Dysfunction in DrosophilaPLOS ONE 3;12(1):e0169073 (2017)

K. Okamoto, Y. Sako: "State transition analysis of spontaneous branch migration of the Holliday junction by photon-based single-molecule fluorescence resonance energy transfer”, Biophys Chem., 209, 21–27 (2016)
Emara S, Amer S, Ali A, Abouleila Y, Oga A, and Masujima T: "Single-Cell Metabolomics" Adv. Exp. Med. Biol. 965: 323-343, 2017

Original Papers 2016

v
Naoe Y, Nakamura N, Doi A, Nakamura H, Shiro Y, and Sugimoto H: “Crystal Structure of Bacterial Heme Importer Complex in Inward-facing Conformation” Nature Communications 7, e13411 (2016)
Yano N, Muramoto K, Shimada A, Takemura S, Baba J, Fujisawa H, Muchizuki M, Shinzawa-Itoh K, Yamashita E, Tsukihara T, Yoshikawa S: “The Mg2+-Containing Water Cluster of Mammalian Cytochrome c Oxidase Four Pumping Proton Equivalents in Each Catalytic Cycle” J. Biol. Chem. 291. 23882-23894 (2016)
Sakaguchi M, Kimura T, Nishida T, Tosha T, Yamaguchi Y, Yanagisawa S, Ueno G, Murakami H, Ago H, Yamamoto M, Ogura T, Shiro Y, and Kubo M: “A Nearly On-axis Spectroscopic System for Simultaneously Measuring UV-visible Absorption and X-ray Diffraction in the SPring-8 Structural Genomics Beamline” J. Synchro. Rad. 23, 334-338 (2016)
Otomo A, Ishikawa H, Mizuno M, Kimura T, Kubo M, Shiro Y, and Mizutani Y: “A Study of the Dynamics of the Heme Pocket and C-helix in CooA upon CO Dissociation Using Time-Resolved Visible and UV Resonance Raman Spectroscopy”, J. Phys. Chem. B 120, 7836-7843 (2016)
Yamawaki T, Ishikawa H, Mizuno M, Nakamura H, Shiro Y, and Mizutani Y: “Regulatory Implications of Structural Changes in Tyr201 of the Oxygen Sensor Protein FixL” Biochemistry 55, 4027–4035 (2016)
Nagamine T, and Sako Y: "A role for anti-viral host defense mechanism in the phylogenetic divergence in baculovirus evolution", PLoS ONE, 11, e0156394 (1-9), (2016)
Murate M, and Kobayashi T: Revisiting transbilayer distribution of lipids in the plasma membrane. Chem Phys Lipids 194, 58-71 (2016)
Yamaji-Hasegawa A, Hullin-Matsuda F, Greimel P, Kobayashi T: "Pore-forming toxins: Properties, diversity, and uses as tools to image sphingomyelin and ceramide phosphoethanolamine", Biochim. Biophys Acta 1858, 576-592 (2016)
Yilmaz N, and Kobayashi T: "Assemblies of Pore-Forming Toxins Visualized by Atomic Force Microscopy Biochim", Biophys Acta 1858, 500-511 (2016)
Kishimoto T, Ishitsuka R, and Kobayashi T: "Detectors for evaluating the cellular landscape of sphingomyelin- and cholesterol-rich membrane domains", Biochim. Biophys Acta 1861, 812-829 (2016)
Hullin-Matsuda F, Makino A, Murate M, Kobayashi T: "Probing phosphoethanolamine-containing lipids in membranes with duramycin/cinnamycin and aegerolysin proteins" Biochimie 130, 81-90 (2016)
Watanabe H, Okahara K, Naito-Matsui Y, Abe M, Go S, Inokuchi J, Okazaki T, Kobayashi T, Kozutsumi Y, Oka S, and Takematsu H: "Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow", Mol Biol Cell 27, 2037-2050 (2016)
Podobnik M, Savory P, Rojiko N, Kisovec M, Wood N, Hambley R, Pugh J, Wallace EJ, McNeill L, Bruce M, Liko I, Allison TM, Mehmood S, Yilmaz N, Kobayashi T, Gilbert RJC, Robinson CV, Jayasinghe K, and Anderluh G: "Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly", Nat Commun 7, 11598 (2016)
Kakisaka M, Yamada K, Yamaji-Hasegawa A, Kobayashi T, and Aida Y: "Intrinsically disordered region of influenza A NP regulates viral genome packaging via interactions with viral RNA and host PI(4,5)P2", Virology 496, 116-126 (2016)
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, Barber GN, Taguchi T, and Arai H: "Activation of STING requires palmitoylation at the Golgi", Nat Commun 7, 11932 (2016)
Jones S, Boisvert A, Naghi A , Hullin−Matsuda F, Greimel P, Kobayashi T, Papadopoulos V, and Culty M: "Stimulation effects of combined endocrine disruptors on MA-10 Leydig cell steroid production and lipid homeostasis", Toxicology 355-356, 21-30 (2016)
Inaba T, Kishimoto T, Murate M, Tajima T, Sakai S, Abe M, Makino A, Tomishige N, Ishitsuka R, Ikeda Y, Takeoka S, and Kobayashi T: "Phospholipase Cβ1 induces membrane tubulation and is involved in caveolae formation" Proc Natl Acad Sci USA 113, 7834-7839 (2016)
Yamada A, Shimizu N, Hikima T, Takata M, Kobayashi T, and Takahashi H: "Effect of cholesterol on the interaction of cytochrome P450 substrate drug chlorzoxazone with the phosphatidylcholine bilayer" Biochemistry 55, 3888-3898 (2016)
Shimizu H, Matsunaga S, Yamada T, Kobayashi T, Kawai M: "Formation of ordered phospholipid monolayer on a hydrophilically modified Au(111) substrate". ACS Nano 10, 7811-7820 (2016)
Makino A, Hullin-Matsuda F, Murate M, Abe M, Tomishige N, Fukuda M, Yamashita S, Fujimoto T, Vidal H, Lagarde M, Delton I, and Kobayashi T: "Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes", Mol Biol Cell 27, 3293-3304 (2016)
Shirota K, Yagi K, Inaba T, Li PC, Murata M, Sugita Y, and Kobayashi T: "Detection of sphingomyelin clusters by Raman spectroscopy" Biophys J 111, 999-1007 (2016)
Venugopal S, Martinez-Arguelles DB, Chebbi S, Hullin-Matsuda F, Kobayashi T, and Papadopoulos V: "Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells", J Biol Chem 291, 26109-26125 (2016)
Ode T, Podyma-Inoue KA, Terasawa K, Inokuchi JI, Kobayashi T, Watabe T, Izumi Y, and Hara-Yokoyama M: "PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum", Exp Cell Res 350, 103-114 (2016)
Okazaki Y, and Saito K: “Integrated metabolomics and phytochemical genomics approaches for studies on rice”, GigaScience, 5, 11 (2016)

Morita H, Moro K, and Koyasu S: Innate lymphoid cells in allergic and non-allergic inflammation. J. Allergy Clin. Immunol. 138: 1253-1264 (2016)

Yamazumi Y, Sasaki O, Imamura M, Oda T, Ohno Y, Shiozaki-Sato Y, Nagai S, Suyama S, Kamoshita Y, Funato K, Yasui T, Kikutani H, Yamamoto K, Dohi M, Koyasu S, and Akiyama T: "The RNA binding protein Mex-3B is required for IL-33 induction in the development of allergic airway inflammation" Cell Rep. 16: 2456-2471 (2016)

Ebrahimi M,Yamamoto Y, Sharifi K, Kida H, Kagawa Y, Yasumoto Y, Islam A, Miyazaki H, Shimamoto C, Maekawa M, Mitsushima D, Yoshikawa T, and Owada Y: "Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons" Glia 64: 48-62, (2016)

Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, and Osumi N: "Maternal dietary balance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites" Stem Cells 34, 470-482 (2016)

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M: "Heterogenous fibroblasts underlie age-dependent tertially lymphoid tissues in the kidney" JCI Insight 1, e87680 (2016)

Endo J, and Arita M: "Cardioprotective mechanism of omega-3 polyunsaturated fatty acids" J Cardiol 67, 22-27 (2016)

Arita M: "Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy" Allergol Int 65, S2-S5 (2016)

Edvardson S, Kose S, Jalas C, Fattal-Valevski A, Watanabe A, Ogawa Y, Mamada H, Fedick AM, Ben-Shachar S, Treff NR, Shaag A, Bale S, Gärtner J, Imamoto N, Elpeleg O: “Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.” J. Med. Genet. 53, 132-137 (2016)

Takagi M, Natsume T, Kanemaki MT, and Imamoto N: "The perichromosomal protein Ki67 supports mitotic chromosome architecture" Genes Cells 21, 1113-1124 (2016)

Mimura Y, Takagi M, Clever M, adn Imamoto N: “ELYS regulates the localization of LBR by modulating its phosphorylation state” J Cell Sci. 129,4200-4212 (2016) (selected as a feature article)

Takayama Y, and Yonekura K: "Cryogenic coherent X-ray diffraction imaging of biological samples at SACLA: a correlative approach with cryo-electron and light microscopy", Acta Crystallogr. A Found. Adv., 72, 179-189 (2016)

Nango E, Akiyama S, Maki-Yonekura S, Ashikawa Y, Kusakabe Y, Krayukhina E, Maruno T, Uchiyama S, Nuemket N, Yonekura K, Shimizu M, Atsumi N, Yasui N, Hikima T, Yamamoto M, Kobayashi Y, Yamashita A: "Taste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domains", Sci. Rep., 6, 25745; doi:10.1038/srep25745 (2016)

Yonekura K, and Maki-Yonekura S: "Refinement of cryo-EM structures using scattering factors of charged atoms", J. Appl. Cryst., 49, 1517–1523 (2016)

Hiyama E, Ali A, Amer S, Harada T, Shimamoto K, Furushima R, Abouleila Y, Emara S, and Masujima T: "Direct Lipido-Metabolomics of Single Floating Cells for Analysis of Circulating Tumor Cells by Live Single-cell Mass Spectrometry" Anal. Sci. 31: 1215-1217, (2015)

Yamamoto K, Takahashi K, Mizuno H, Anegawa A, Ishizaki K, Fukaki H, Ohnishi M, Yamazaki M, Masujima T, and Mimura T: "Cell-specific localization of alkaloids in Catharanthus roseus stem tissue measured with Imaging MS and Single-cell MS" Proc. Natl. Acad. Sci. U S A 113: 3891-3896, (2016)

Horiyama S, Hatai M, Takahashi Y, Date S, Masujima T, Honda C, Ichikawa A, Yoshikawa N, Nakamura K, Kunitomo M, and Takayama M: "Intracellular Metabolism of α,β-Unsaturated Carbonyl Compounds, Acrolein, Crotonaldehyde and Methyl Vinyl Ketone, Active Toxicants in Cigarette Smoke: Participation of Glutathione Conjugation Ability and Aldehyde-Ketone Sensitive Reductase Activity" Chem. Pharm. Bull. (Tokyo) 64: 585-593, (2016)

Tanaka M, Esaki T, Kenmoku H, Koeduka T, Kiyoyama Y, Masujima T, Asakawa Y, and Matsui K: "Direct evidence of specific localization of sesquiterpenes and marchantin A in oil body cells of Marchantia polymorpha L" Phytochemistry 130: 77-84, (2016)

Ali A, Abouleila Y, Amer S, Furushima R, Emara S, Equis S, Cotte Y, and Masujima T: "Quantitative Live Single-cell Mass Spectrometry with Spatial Evaluation by Three-Dimensional Holographic and Tomographic Laser Microscopy" Anal. Sci. 32: 125-127, (2016)

Singh PC, Inoue K, Nihonyanagi S, Yamaguchi S, and Tahara T: “Femtosecond hydrogen-bond dynamics of bulk-like and bound water at positively and negatively charged lipid interfaces revealed by 2D HD-VSFG spectroscopy”, Angew. Chem. Int. Ed., 55, 10621 –10625 (2016).

Kaddai VA, Lancaster GI, Henstridge DC, Sriram S, Galam DL, Gopalan V, Prakash KN, Velan SS, Bulchand S, Tsong TJ, Wang M,Siddique MM, Yuguang G, Sigmundsson K, Mellet NA, Weir JM, Meikle PJ, Bin M Y Yassin MS, Shabbir A, Syayman JA, Hirabayashi Y, Shiow ST, Sugii S, Summers SA: “Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism. ” Cell Metabolism Vol.24(6):820-834 (2016)

Akiyama H, Nakajima K, Itoh Y, Sayano T, Ohashi Y, Yamaguchi Y, Greimel P, Hirabayashi Y:“Aglycon Diversity of brain sterylglucosides: structure determination of cholesteryl- and sitosterylglucoside” J. Lipid Res.57(11), 2061-2072 (2016)

Nakajima K, Akiyama H, Tanaka K, Kohyama-Koganeya A, Greimel P, Hirabayashi Y:“Separation and analysis of mono-glucosylated lipids in brain and skin by hydrophilic interaction chromatography based on carbohydrate and lipid moiety” Journal of Chromatography B 1031,146-153 (2016)

Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S: “Cell-free methods to produce structurally intact mammalian membrane proteins”Sci Rep. 6,30442(2016)

Bouskila J, Harrar V, Javadi P, Casanova C, Hirabayashi Y, Matsuo I, Ohyama J: “Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55” Visual Neuroscience 33 (2016)

Sayano T, Kawano Y, Kusada W, Arimoto Y, Esaki K, Hamano M, Udono M, Katakura Y, Ogawa T, Kato H, Hirabayashi Y and Furuya S:  “Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts” FEBS Open Bio 6 ,303-316 (2016).

Marques AR, Mirzaian M, Akiyama H, Wisse P, Ferraz MJ, Gaspar P, Ghauharali-van der Vlugt K, Meijer R, Giraldo P, Alfonso P, Irún P, Dahl M, Karlsson S, Pavlova EV, Cox TM, Scheij S, Verhoek M, Ottenhoff R, van Roomen CP, Pannu NS, van Eijk M, Dekker N, Boot RG, Overkleeft HS, Blommaart E, Hirabayashi Y, Aerts JM: “Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases” J. Lipid Res.57(3) ,451-463 (2016)

Nakamura Y, Hibino K, Yanagida T, Sako Y: "Switching of the positive feedback for RAS activation by a concerted function of SOS membrane association domains" Biophysics and Physicobiology, vol 13, 1-11 (2016)
Arata Y, Hiroshima M, Pack CG, Ramanujam R, Motegi F, Nakazato K, Shindo Y, Wiseman PW, Sawa H, Kobayashi TJ, Brandao HB, Shibata T, Sako Y: "Cortical Polarity of the RING Protein PAR-2 is Maintained by Exchange Rate Kinetics at the Cortical-Cytoplasmic Boundary" Cell Reports 16(8):2156-2168 (2016)
Y. Shindo, K. Iwamoto, K. Mouri, K. Hibino, M. Tomita, H. Kosako, Y. Sako, K. Takahashi: "Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling”, Nature Communications 7, Article number: 10485 (2016)
K. Okamoto, Y. Sako: "State transition analysis of spontaneous branch migration of the Holliday junction by photon-based single-molecule fluorescence resonance energy transfer”, Biophys Chem., 209, 21–27 (2016)
E. Leroy, JP. Defour, T. Sato, S. Dass, V. Gryshkova, SM. Marlar, J. Staerk, SN. Constantinescu, SO. Smith: "His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor”, J. Biol. Chem., 291, 2974-2987 (2016)
T. Sato: "Synthetic transmembrane-juxtamembrane peptide for the structure and function of ErbB receptor tyrosine kinase”, Biopolymers, in press (2016)

Original Papers 2015

Iwata S, Masuhara K, Umeki N, Sako Y, and Maruta S: "Interaction of a novel fluorescent GTP analogue with the small G-protein K-Ras", J. Biochem. 159, 41-48.(2015)

Zhou Y, Mao H, Joddar B, Umeki N, Sako Y, Nishioka C, Takahashi E, Wada K, Wang Y, and Ito Y: "The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness", Sci. Rep. 5, 11386 (1-13),(2015)

Arata Y, Takagi H, Sako Y, and Sawa, H: "Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans", Frontiers in Physiol. DOI: 10.3389/fphys.2014.00529 (1-11), (2015)

Lee S, Uchida Y, Wang J, Matsudaira T, Nakagawa T, Kishimoto T, Mukai K, Inaba T, Kobayashi T, Molday RS, Taguchi T, and Arai H: "Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase", EMBO J 34, 669-688 (2015)

Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, and Takamori K: "Properties and functions of lactosylceramide from mouse neutrophils", Glycobiology 25, 655-668 (2015)

Takagishi T, Oda M, Kabura M, Kurosawa M, Tominaga K, Urano S, Ueda Y, Kobayashi K, Kobayashi T, Sakurai J, Terao Y, and Nagahama M: "Clostridium perfringens alpha-toxin induces GM1a clustering and TrkA phosphorylation in the host cell membrane", PLoS one 10, e0120497 (2015)

Matsunaga S, Yamada T, Kobayashi T, Kawai M: "Scanning tunneling microscopic observation of the phosphatidylserine domains in the phosphatidylcholine monolayer", Langmuir 31, 5449-5455 (2015)

Arita Y, Nishimura S, Ishitsuka R, Kishimoto T, Ikenouchi J, Ishii K, Umeda M, Matsunaga S, Kobayashi T, and Yoshida M: "Targeting cholesterol in a liquid-disordered environment by theonellamides modulates cell membrane order and cell shape", Chem Biol 22, 604-610(2015)

Ogawa R, Nagao K, Taniuchi K, Tsuchiya M, Hara Y, Inaba T, Kobayashi T, Sasaki Y, Akiyoshi K, Watanabe-Takahashi M, Nishikawa K, and Umeda M: "Development of a novel tetravalent synthetic peptide that binds to phosphatidic acid", PLoS ONE 10, e0131668 (2015)

Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S.: "Deficiency in the lipid exporter ABCA1 impairs retrograde sterol movement and disrupts sterol sensing at the endoplasmic reticulum", J Biol Chem 290, 23464-23477 (2015)

Ikeda A, Kajiwara K, Iwamoto K, Makino A, Kobayashi T, Mizuta K, and Funato K: "Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis", Yeast 33, 37-42 (2015)

Yagi K, Li PC, Shirota K, Kobayashi T, Sugita Y: "A weight averaged approach for predicting amide vibrational bands of a sphingomyelin bilayer", Phys Chem Chem Phys 17, 29113-29123 (2015)

Wakana Y, Kotake R, Oyama N, Murate M, Kobayashi T, Arasaki K, Inoue H, and Tagaya M: "CARTS biogenesis is regulated by VAP-lipid transfer protein complexes at the endoplasmic reticulum-Golgi interface", Mol Biol Cell 26, 4686-4699 (2015)

Y. Higashi, Y. Okazaki, F. Myouga, K. Shinozaki, and K. Saito: “Landscape of the lipidome and transcriptome under heat stress in Arabidopsis thaliana” Scientific Reports, 5, 10533 (2015)

Emara S, Masujima T, Zarad W, Kamal M, Fouad M, and El-Bagary R: "An Eco-Friendly Direct Injection HPLC Method for Methyldopa Determination in Serum by Mixed-Mode Chromatography Using a Single Protein-Coated Column" J. Chromatogr. Sci. 53: 1353-1360, 2015

Shimizu T, Miyakawa S, Esaki T, Mizuno H, Masujima T, Koshiba T, and Seo M: "Live Single-Cell Plant Hormone Analysis by Video-Mass Spectrometry" Plant Cell Physiol. 56: 1287-1296, (2015)

Fujita H, Esaki T, Masujima T, Hotta A, Kim SH, Noji H, Watanabe TM: "Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry" RSC Adv. 5: 16968-16971, (2015)

Fujii T, Matsuda S, Tejedor ML, Esaki T, Sakane I, Mizuno H, Tsuyama N, and Masujima T: "Direct metabolomics for plant cells by live single-cell mass spectrometry" Nat. Protoc. 10: 1445-1456, (2015)

Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, and Tomita T: "Cooperative roles of hydrophilic loop 1 and the C terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase." J. Neurosci. 35, 2646-2656, (2015)

Suzuki M, Fujikake N, Takeuchi T, Kohyama-Koganeya A, Nakajima K, Hirabayashi Y, Wada K, Nagai Y: “Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease” Hum Mol Genet 2015,1-12 (2015)
Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, Kamiguchi H: "NEURONAL DEVELOPMENT. Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord” Science 349(6251), 974-977 (2015)

Ishibashi Y, Hirabayashi Y: "AMP-activated Protein Kinase Suppresses Biosynthesis of Glucosylceramide by Reducing Intracellular Sugar Nucleotides” J Biol Chem 290(29), 18245-18260 (2015).

Kohyama-Koganeya A, Kurosawa M, Hirabayashi Y: “Differential Effects of Tissue-Specific Deletion of BOSS on Feeding Behaviors and Energy Metabolism” PLoS One 10(7), e0133083 (2015).
Esaki K, Sayano T, Sonoda C, Akagi T, Suzuki T, Ogawa T, Okamoto M, Yoshikawa T, Hirabayashi Y, Furuya S: “l-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation” J Biol Chem 290(23), 14595-14609 (2015)
K. Moro, H. Kabata, M. Tanabe, S. Koga, N. Takeno, M. Mochizuki, K. Fukunaga, K. Asano, T. Betsuyaku, S. Koyasu : "Interferon and IL-27 antagonize group 2 innate lymphoid cell function and type 2 innate immune responses”, Nat. I mmunol., in press (2015)
M. Maekawa, Y. Iwayama, T. Ohnishi, M. Toyoshima, C. Shimamoto, Y. Hisano, T. Toyota, S. Balan, H. Matsuzaki, Y. Iwata, S. Takagai, K. Yamada, M. Ota, S. Fukuchi, Y. Okada, W. Akamatsu, M. Tsujii, N. Kojima, Y. Owada, H. Okano, N. Mori, T. Yoshikawa : "Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism”;, Sci. Rep., in press.
N. Yilmaz and T. Kobayashi : "Visualization of lipid membrane reorganization Induced by a pore-forming toxin using high-speed atomic force microscopy", ACS Nano 9, 7960-7967.
Y. Ueda, H. Ogiso, M. Sato, Y. Umezawa, T. Okazaki, and T. Kobayashi : "Asymmetrical diacylglycerol dynamics on the cytosolic and lumenal sides of a single endomembrane in living cells", Sci. Rep., 5, 12960.
H. B. Bhat, R. Ishitsuka, T. Inaba, M. Murate, M. Abe, A. Makino, A. Kohyama-Koganeya, A. Kurahashi, T. Kishimoto, M. Tahara, A. Yamano, K. Nagamune, Y. Hirabayashi, N. Jyuni, M. Umeda, F. Fujimori, K. Nishibori, A. Yamaji-Hasegawa, P. Greimel, and T. Kobayashi : "Evaluation of aegerolysins as novel tools to detect and visualize ceramide phosphoethanolamine, a major sphingolipid in invertebrates", FASEB J., 29, 3920-3934.
A. Vasanthakumar, K. Moro, A. Xin, Y. Liao, R. Gloury, S. Kawamoto, S. Fagarasan, L A. Mielke, S. Afshar-Sterle, L. Seth, S. L. Masters, S. Nakae, H. Saito, J. M. Wentworth, P. Li, W. Liao, W. J. Leonard, G. K. Smyth, W. Shi, S. L. Nutt, S. Koyasu, A. Kallies : “The transcriptional regulators IRF4 and BATF and interleukin 33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells”, Nat. Immunol., 16, 276-285 (2015).
M. Yanagawa, K. Kojima, T. Yamashita, Y. Imamoto, T. Matsuyama, K. Nakanishi, Y. Yamano, A. Wada, Y. Sako, Y. Shichida : "Origin of the low thermal isomerization rate of rhodopsin chromophore”, Sci. Rep., 5, 11081 (2015)
S. Takanezawa, S. Morita, Y. Ozaki, Y. Sako : "Raman spectral dynamics of single cells in the early stages of growth factor stimulation”, Biophys J., 108, 2148-57 (2015)
M. Murate, M. Abe, K. Kasahara, K. Iwabuchi, M. Umeda, and T. Kobayashi : "Transbilayer distribution of lipids at nano scale", J. Cell Sci., 128, 1627-1638 (2015).
A. Makino, M. Abe, M. Murate, T. Inaba, N. Yilmaz, F. Hullin-Matsuda, T. Kishimoto, N. L. Schieber, T. Taguchi, H. Arai, G. Anderluh, R. G. Parton, and T. Kobayashi : "Visualization of the heterogeneous membrane distribution of sphingomyelin associated with cytokinesis, cell polarity, and sphingolipidosis", FASEB J., 29, 477-493 (2015).
Y. Okazaki, T. Nishizawa, K. Takano, M. Ohnishi., T. Mimura, and K. Saito : "Induced accumulation of glucuronosyldiacylglycerol in tomato and soybean under phosphorus deprivation", Physiol. Plant., in press.
K. Inoue, S. Nihonyanagi, P. C. Singh, S. Yamaguchi, and T. Tahara : "2D heterodyne-detected sum frequency generation study on the ultrafast vibrational dynamics of H2O and HOD water at charged interfaces", J. Chem. Phys., 142, 212431-1~12 (2015).

Original Papers 2014

CG. Pack, H. Yukii, A. Toh-e, T. Kudo, H. Tsuchiya, A. Kaiho, E. Sakata, S. Murata, Y. Yokosawa, Y. Sako, W. Boumeister, K. Tanaka, and Y. Saeki: "Quantitative live-cell imaging reveals spatio-temporal and cytoplasmic assembly of the 26S proteasome", Nat. Commn. 5, 4396 (1-10) (2014)
R. Maeda, M. Hiroshima, A. Wada, S. Nishimura, Y. Sako, Y. Shichida, and Y. Imamoto: "Single-molecule observation of the ligand-induced population shift of rhodopsin, a G-protein coupled receptor", Biophys. J., 106, 915-924 (2014)
Srimontri P, Endo S, Sakamoto T, Nakayama Y, Kurosaka A, Itohara S, Hirabayashi Y, Kato K: “Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy” Journal of Neurochemistry 131(5), 675-687 (2014)
Y. Ueda, R. Ishitsuka, F. Hullin-Matsuda, and T. Kobayashi : "Regulation of the transbilayer movement of diacylglycerol in the plasma membrane", Biochimie, 107, 43-50 (2014).
F. Hullin-Matsuda, T. Taguchi, P. Greimel, and T. Kobayashi : "Lipid compartmentalization in the endosome system", Sem. Cell Dev. Biol., 31, 48-56 (2014).
M. Abe and T. Kobayashi : "Imaging local sphingomyelin-rich domains in the plasma membrane using specific probes and advanced microscopy", Biochim. Biophys. Acta, 1841, 720-726 (2014).
T. Kind, Y. Okazaki, K. Saito, and O. Fiehn : "LipidBlast templates as flexible tools for creating new in-silico tandem mass spectral libraries", Anal. Chem., 86, 11024-11027 (2014).
S. Nihonyanagi, S. Yamaguchi, and T. Tahara : "Counterion effect on interfacial water at charged interfaces and its relevance to the hofmeister series", J. Am. Chem. Soc., 136, 6155-6158 (2014).
P. C. Singh, S. Nohonyanagi, S. Yamaguchi, and T. Tahara : "Interfacial water in the vicinity of a positively charged interface studied by steady-state and time-resolved heterodyne vibrational sum-frequency generation", J. Chem. Phys., 141, 18C527-1~7 (2014).
J. Endo, M. Sano, Y. Isobe, K. Fukuda, J. X. Kang, H. Arai, and M. Arita : "18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling", J. Exp. Med., 211, 1673-1687 (2014).
Y. Yokokura, Y. Isobe, S. Matsueda, R. Iwamoto, T. Goto, T. Yoshioka, D. Urabe, M. Inoue, H. Arai, and M. Arita : "Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite", J. Biochem., 156, 315-321 (2014).
Y. Tani, Y. Isobe, Y. Imoto, E. Segi-Nishida, Y. Sugimoto, H. Arai, and M. Arita : "Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice", FASEB J., 28, 4036-4043 (2014).
T. Kubota, M. Arita, Y. Isobe, R. Iwamoto, T. Goto, T. Yoshioka, D. Urabe, M. Inoue, H. Arai : "Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid", FASEB J. 28, 586-593 (2014).
K. Yugi, H. Kubota, Y. Toyoshima, R. Noguchi, K. Kawata, Y. Komori, S. Uda, K. Kunida, Y. Tomizawa, Y. Funato, H. Miki, M. Matsumoto, K. I. Nakayama, K. Kashikura, K. Endo, K. Ikeda, T. Soga, and S. Kuroda : "Reconstruction of insulin signal flow from phosphoproteome and metabolome data", Cell Rep., 8, (2014).
Y. Arata, H. Takagi, Y. Sako, and H. Sawa : "Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans", Frontiers in Physiol. 2014, 00529 (1-11) (2014).
H. Park, S.-S. Han, Y. Sako, and C.-G. Pack : "Dynamic and unique nucleolar microenvironment revealed by fluorescence correlation spectroscopy", FASEB J. 29, 837-848 (2014).
H. Shinohara, M. Behar, K. Inoue, M. Hiroshima, T. Yasusda, T. Nagashima, S. Kimura, H. Sanjo, S. Maeda, N. Yumoto, S. Ki, S. Akira, Y. Sako, A. Hoffman, T. Kurosaki,, and M. Okada-Hatakeyama : "Positive feedback within a kinase signaling complex functions as a switch mechanism for NFkB activation", Science 344, 760-764 (2014).
S. Morita, S. Takanezawa, M. Hiroshima, T. Mitsui, Y. Ozaki, and Y. Sako : "Raman and autofluorescence spectrum dynamics along the HRG-induced differentiation pathway of MCF-7 cells", Biophys. J., 107, 2840-2848 (2014).
S. Re, W. Nishima, T. Tahara, and Y. Sugita : "Mosaic of water orientation structures at a neutral zwitterionic lipid/water interface revealed by molecular dynamics simulations", J. Phys. Chem. Lett., 5, 4343-4348 (2014).
Y. Komuro, S. Re, C. Kobayashi, E. Muneyuki, and Y. Sugita : "CHARMM force-fields with modified polyphosphate parameters allow stable simulation of the ATP bound structure of Ca2+-ATPase", J. Chem. Theor. Comput. 10, 4133-4142 (2014).
P. Li, N. Miyashita, W. Im, S. Ishido, and Y. Sugita : "Multidimensional umbrella sampling and replica-exchange molecular dynamics simulations for structure prediction of transmembrane helix dimer", J. Comput. Chem., 35, 300-308 (2014).
S. Takahashi, S. Nagano, T. Nogawa, N. Kanoh, M. Uramoto, M. Kawatani, T. Shimizu, T. Miyazawa, Y. Shiro, H. Osada : "Structure-function analyses of cytochrome P450revl involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T", J. Biol. Chem., 289, 32446-23458 (2014).
K. Takagi, M. Al-Amin, N. Hoshiya, J. Wouters, H. Sugimoto, Y. Shiro, H. Fukuda, S. Shuto, M. Arisawa : "Palladium-nanoparticle-catalyzed 1, 7-palladium migration involving C-H activation, followed by intramolecular amination; regioselective synthesis of N1-arylbenzotiazoles and an evaluation of their inhibitory activity toward indoleamine 2, 3-dioxygenase", J. Org. Chem., 79, 6366-6371 (2014).
C. Shirataki, O. Shoji, M. Terada, S. Ozaki, H. Sugimoto, Y. Shiro, Y. Watanabe : "Inhibition of heme uptake in Pseudomonas aeruginosa by its hemophore (HsaA(p)) bound to synthetic metal complexes", Angew Chem Int Ed Engl., 53, 2862-2866 (2014).
N. Sato, S. Ishii, H. Sugimoto, T. Hino, Y. Fukumori, Y. Sako, Y. Shiro, and T. Tosha : "Structures of reduced and ligand-bound nitric oxide reductase provide insights into functional differences in respiratory enzymes", PROTEINS: Structure, Function, and Bioinformatics, 82, 1258-1271 (2014).
E. Terasaka, N. Okada, N. Sato, Y. Sako, Y. Shiro, and T. Tosha : "Characterization of quinol-dependent nitric oxide reductase from Geobacillus Stearothermophilus: Enzymatic activity and active site structure", Special Issue on Respiratory Oxidases in Biochim. Biophys. Acta – Bioenergetics, 1837, 1019-1026 (2014).
H. Tsujino, T. Yamashita, A. Nose, K. Kukino, H. Sawai, Y. Shiro, and T. Uno : "Disulfide bonds regulate binding of exogenous ligand to human cytoglobin", J. Inor. Biochem., 135, 20-27 (2014).
Y. Okamoto, H. Sawai, M. Ogura, T. Uchida, K. Ishimori, T. Hayashi, and S. Aono : "Heme-binding properties of HupD functioning as a substrate-binding protein in a heme-uptake ABC-transporter system in Listeria monocytogenes", Bull. Chem. Soc. Japan, 87, 1140-1146 (2014).
K. Okahara, Y. Kizuka, S. Kitazume, F. Ota, K. Nakajima, Y. Hirabayashi, M. Maekawa, T. Yoshikawa, and N. Taniguchi : "Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2", Glycobiology, 24, 926-934 (2014).
G. J. Huang, A. Edwards, C.-Y. Tsai, Y.-S. Lee, L. Peng, T. Era, Y. Hirabayashi, C.-Y. Tsai, S. Nishikawa, Y. Iwakura, S.-J. Chen, and J. Flint : "Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice", PLoS One, 9, e86471 (2014).
K. Hirata, K. Shinzawa-Itoh, N. Yano, S. Takemura, K. Kato, M. Hatanaka, K. Muramoto, T. Kawahara, T. Tsukihara, E. Yamashita, K. Tono, G. Ueno, T. Hikima, H. Murakami, Y. Inubushi, M. Yabashi, T. Ishikawa, M. Yamamoto, T. Ogura, H. Sugimoto, J. R. Shen, S. Yoshikawa, and H. Ago : "Determination of damage-free crystal structure of an X-ray-sensitive protein using an XFEL", Nature Methods, 11, 734-736 (2014).
R. Xu, H. Jiang, C. Song, Z. Huang, J. A. Rodriguez, C-C. Chen, D. Nam, J. Park, M. Gallagher-Jones, S. Kim, S. Kim, A. Suzuki, Y. Takayama, T. Oroguchi, Y. Takahashi, J. Fan, Y. Zou, T. Hatsui, Y. Inubushi, T. Kameshima, K. Yonekura, K. Tono, T. Togashi, T. Sato, M. Yamamoto, M. Nakasako, M. Yabashi, T. Ishikawa, and J. Miao : "Single shot three-dimensional imaging of high-index-faceted nanocrystals with femtosecond X-ray free electron laser pulses", Nat. Commun. 5, 4061 (2014).
H. Tamagaki, Y. Furukawa, R. Yamaguchi, H. Hojo, S. Aimoto, S. O. Smith, and T. Sato : "Coupling of transmembrane helix orientation to membrane release of the juxtamembrane region in FGFR3", Biochemistry, 53, 5000-5007 (2014).
M. Miyashita M. Arai, H. Yuzawa, K. Niizato, K. Oshima, I. Kushima, R. Hashimoto, M. Fukumoto, S. Koike, T. Toyota, H. Ujike, T. Arinami, K. Kasai, M. Takeda, N. Ozaki, Y. Okazaki, T. Yoshikawa, N. Amano, T. Miyata, and M. Itokawa : "Replication of enhanced carbonyl stress in a subpopulation of schizophrenia", Psychiatry and Clinical Neurosciences, 68, 83-84 (2014).
T. Ohnishi, T. Murata, A. Watanabe, A. Hida, H. Ohba, Y. Iwayama, A. Mishima, Y. Gondo, and T. Yoshikawa : "Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis". J. Biol. Chemistry, 289, 10785-10796 (2014).
M. Miyashita, M. Arai, A. Kobori, T. Ichikawa, K. Toriumi, K. Niizato, K. Oshima, Y. Okazaki, T. Yoshikawa, N. Amano, T. Miyata, and M. Itokawa : "Clinical features of schizophrenia with enhanced carbonyl stress", Schizophrenia Bulletin, 40, 1040-1046 (2014).
C. Shimamoto, T. Ohnishi, M. Maekawa, A. Watanabe, H. Ohba, R. Arai, Y. Iwayama, Y. Hisano, T. Toyota, M. Toyoshima, K. Suzuki, K. Nakamura, N. Mori, Y. Owada, T. Kobayashi, and T. Yoshikawa : "Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies", Hum. Mol. Genet., 23, 6495-6511 (2014).
C. Song, M. Takagi, J. Park, R. Xu, M. Gallagher-Jones, N. Imamoto, and T. Ishikawa : "Analytic 3D imaging of mammalian nucleus at nanoscale using coherent X-Rays and optical fluorescence microscopy", Biophys. J., 107, 1074-1081 (2014).
M. Takagi, Y. Nishiyama, A. Taguchi, and N. Imamoto: "Ki67 antigen contributes to the timely accumulation of protein phosphatase 1g on anaphase chromosomes", J. Biol. Chem., 289, 22877-22887 (2014).
S. Kose and N. Imamoro : "Nucleocytoplasmic transport under stress conditions and its role in HSP70 chaperone systems", BBA-General Subjects, 1840, 2953-2960 (2014).
D. Booth, M. Takagi, L. Sanchez-Pulido, E. Petfalski, G. Vargiu, K. Samejima, N. Imamoto, C. P. Pnting, D. Tollervey, W. Earnshaw, and P. Vagnarelli : "Ki-67 is a PP1-interacting protein that organizes the mitotic chromosome periphery", eLife, 3, e01641 (2014).
Y. Oda, M. Kimura, S. Kose, M. B. Fasken, A. H. Corbett, and N. Imamoto : "The Schizosaccharomyces pombe "Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but act in different physiological contexts", FEBS Lett., 588, 1899-1905 (2014).
M. Kimura and N. Imamoto : "Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways", Traffic, 15, 727-748 (2014).
V. Mackel, W. Meissl, T. Ikeda, M. Clever, E. Meissl, T. Kobayashi, T. M. Kojima, N. Imamoto, K. Ogiwara, and Y. Yamazaki : "A novel facility for 3-D micro-irradiation of living cells in a controlled environment by MeV ions", Review of Scientific Instruments, 85, 014302 (2014).
F. Yasui, M. Kohara, M. Kitabatake, T. Nishiwaki, H. Fujii, C. Tateno, M. Yoneda, K. Morita, K. Matsushima, S. Koyasu, and C. Kai : "Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS-associated coronavirus", Virology, 454-455,157-168 (2014).
Y. Motomura, H. Morita, K. Moro, S. Nakae, D. Artis, T. A. Endo, Y. Kuroki, O. Ohara, S. Koyasu, and M. Kubo : "Basophil-derived IL-4 controls the function of natural helper cells in lung inflammation", Immunity, 40, 758-771 (2014).
K. Yoshioka, K. Ishii, T. Kuramoto, S. Nagai, H. Funao, H. Ishihama, Y. Shiono, A. Sasaki, M. Aizawa, Y. Okada, S. Koyasu, Y. Toyama, and M. Matsumoto : "A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth", PLoS One, 9, e106367 (2014).

Books and Reviews 2017

H. Sawai, Y. Shiro: “Haem-based Sensors of Dioxygen” Chapter 3 of RCS Metallobiology Series, Gas Sensing in Cells, Ed by S. Aono, The Royal Society of Chemistry, (2017) in press
H. Akiyama, Y. Hirabayashi: “A novel function for glucocerebrosidase as a regulator of sterylglucoside metabolism ”, Biochim Biophys Acta. pii: S0304-4165(17)30189-7. (2017)
R. Iino, T. Iida, A. Nakamura, E. Saita, H. You, and Y. Sako: "Single-molecule imaging and manipulation of biomolecular and systems", Biochem. Biophys. Acta. in press.(2017)
K. Okamoto, and Y. Sako: "Recent advances in FRET for the study of protein interactions and dynamics", Curr. Opin. Strct. Biol. 46, 16-23 (2017)

Books and Reviews 2016

T. Tosha, and Y. Shiro: “Structure and Function of Nitric Oxide Reductases” Chapter 6 of RSC Metallobiology Series, Metalloenzymes in Denitrification: Applications and Environmental Impacts, Eds by I. Moura, J. G. Moura, S. R. Pauleta and L. B. Maia, The Royal Society of Chemistry (2016) pp.114-140
Y. Takayama, and K. Yonekura: "Signal enhancement and Patterson-search phasing for higher-spatial-resolution coherent X-ray diffraction imaging of biological objects", SPring-8/SACLA Research Frontiers 2015, 132-133 (2016)

Books and Reviews 2015

S. Kose, T. Funakoshi, and N. Imamoto : "Reconstitution of nucleocytoplasmic transport using digitonin-permeabilized cells", Methods Mol. Biol., 1262, 291-303 (2015).
S. Koyasu : "News and Views: Inflammatory ILC2 cells: disguising themselves as progenitor cells?", Nat. Immunol., 16, 133-134 (2015).
H. Kabata, K. Moro, S. Koyasu, and K. Asano : "Group 2 innate lymphoid cells and asthma", Allergol. Int., 64, 227-234 (2015).

Books and Reviews 2014

Y. Okazaki and K. Saito : "Roles of lipids as signaling molecules and mitigators during stress response in plants", Plant J. 79, 584-596 (2014).
C.-G. Pack, M. K. Jung, M. R., Song, J. -S. Kim, S.-S. Han, and Y. Sako, : "Use of engineered nanoparticle-based fluorescence methods for live-cell phenomena", Fluorescence Microscopy: Super-Resolution and Other Novel Techniques, (Elsevier) pp.153-170 (2014).
J. Inokuchi, S. Go, and Y. Hirabayashi : "Synthesis of O-Linked Glycoconjugates in the Nervous System", Glycobiology of the Nervous System, 9, 71-87 (2014).
K. Nakajima, A. Kohyama-Koganeya, and Y. Hirabayashi : "Profiling of Glucosylceramides by Liquid Chromatography-Tandem Mass Spectrometry", Glycoscience: Biology and Medicine, 1-7 (2014).
M. Takagi and N. Imamoto : "Control of Nuclear Size by NPC proteins. In Cancer biology and Nuclear Envelope" Adv. Exp. Med. Biol., 773, 571-591 (2014).
M. Furuta, S. Kose, R. H. Kehlenbach, and N. Imamoto : "Analysis of nucleocytoplasmic transport in digitonin-permeabilized cells under different cellular conditions", Methods Cell Biol., 122, 331-352 (2014).
K. Maeshima, T. Funakoshi, and N. Imamoto : "Cell fusion method to visualize interphase nuclear pore formation", Methods Cell Biol., 122, 239-254 (2014).
M. Kimura, K. Thakar, S. Karaca, N. Imamoto, and R. Kehlenbach : "Novel approaches for identification of nuclear transport receptor substrates", Methods Cell Biol., 122, 353-378 (2014).
A. Diefenbach, M. Colonna, and S. Koyasu : "Development, differentiation, and diversity of innate lymphoid cells", Immunity 41, 354-365 (2014).
K. Moro and S. Koyasu : "Microbiome and innate lymphoid cells", Semin. Immunopathol., 37, 27-37 (2014).

Books and Reviews (in Japanese) 2016

廣島通夫, 佐甲靖志: "蛍光1分子可視化技術と超局在化顕微鏡法" 実験医学別冊「初めてでもできる!超解像イメージング」岡田康志編, 羊土社, 213-218. (2016)
新土優樹, 小迫英尊, 佐甲靖志, 高橋恒一: "細胞内シグナルのアナログ・デジタル変換", 生物物理 56, 334-336. (2016)
Akiyama H, Hirabayashi Y: “脳における新たなステロール代謝経路:糖化ステロール群の発見” JSBMS Letters 41,43-46(2016)
Nagatuka Y, Nakajima K, Hirabayashi Y: “新しい脳脂質 ホスファチジルグルコシドとそのリゾ体脂質の生物機能” 生体の科学67(3),227-231(2016).

Books and Reviews (in Japanese) 2015

秋山央子、香山綾子、平林義雄:“第6章 細胞内脂質シグナル関連因子、第7節 糖脂質代謝酵素”, モデル動物利用マニュアル 疾患モデルの作製と利用-脂質代謝異常と関連疾患,(エル・アイ・シー), 下巻, 361-385 (2015)
佐甲靖志: "光学顕微鏡の過去・現在・未来", 生物物理 55, 317-321. (2015).
升島 努 : "1細胞メタボローム(特集 次世代生物学の扉を開く1細胞解析法)Single-Cell Metabolomics", 細胞工学, 34, 273-277 (2015).
小安重夫 : "大学は今のままで学術研究を担っていけるのか?", IDE 現代の高等教育,(IDE大学協会)568, 21-26 (2015).

Books and Reviews (in Japanese) 2014

水野 初, 津山尚宏, 升島 努 : "単一細胞ダイレクト質量分析法による細胞内小器官メタボロミクス",分析化学, 63, 477-484 (2014).
升島 努 : "1細胞質量分析法によるin situダイレクト分子動態追跡", 生体の科学, 404-405 (2014).
藤田 愛, 江崎剛史, 伊達沙智子, 水野 初, 升島 努 : "1細胞レベルの網羅的分子解析―メタボロミクス", 生体の科学, 271-277 (2014).
岡咲洋三、斉藤和季 : "リン欠乏条件下で必須の機能をもつ糖脂質グルクロノシルジアシルグリセロールの発見", 化学と生物, 52, 145-147 (2014).
井上賢一、Prashant C. Singh、二本柳聡史、山口祥一、田原太平:"時間分解ヘテロダイン検出振動和周波発生分光法を用いた水界面の超高速振動ダイナミクスの研究"、表面科学、35, 662-667 (2014).
石井邦彦:"生命科学のための蛍光分光 第5回 蛍光分子の動的過程の解析2", 分光研究, 63, 215-227 (2014).
乙須拓洋:"二次元蛍光寿命相関分光法によるマイクロ秒蛋白質ダイナミクス研究", 生物物理, 54, 321-322 (2014).
二本柳聡史、山口祥一、田原太平: "ヘテロイン検出和周波発生分光法による水界面における水素結合構造とダイナミクスの解明", Electrochemistry, 82, 766-770, (2014).
小林哲幸、有田誠: "第1章:脂質の構造と代謝", 生体膜の分子機構(梅田真郷/編)化学同人1-39 (2014).
有田誠:"脂肪酸代謝バランスと炎症の制御", 実験医学増刊号「炎症」(羊土社), 32, 2796-2802 (2014).
有田誠:"炎症を制御する脂肪酸代謝物の包括的メタボロミクス", 医学のあゆみ(医歯薬出版), 248, 1199-1204 (2014).
有田誠:"炎症の収束に関わる脂質メディエーター", 炎症と免疫(先端医学社), 22, 79-84 (2014).
藤井 浩、城 宜嗣:"鉄タンパク質・酵素の構造と機能", 「鉄の事典」(朝倉書店) (2014).
佐藤 毅: "ペプチド化学を基礎とした受容体型チロシンキナーゼ膜貫通—膜近傍部位の構造解析", 化学工業65, (11),15-21 (2014).
佐藤 毅: "受容体型チロシンキナーゼにおける膜を介した情報伝達のしくみ" , 生物物理, 313, (2014).
Hirabayashi
Y. Hirabayashi, H. Akiyama, and K. Nakajima, : "糖脂質の新機能-多様な脂質のグルコース修飾機構と意義", 生化学, 86, 735-743 (2014).
H. Akiyama and Y. Hirabayashi : "あらたなグルコース化脂質の存在と役割", 生命を支える脂質-最新の研究と臨床, 248, 1031-1036 (2014).